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目的探讨临床对系统性红斑狼疮应用羟氯喹治疗的临床有效性.方法随机选取本院2012年~2014年收治系统性红斑狼疮患者54例,根据治疗方法的不同将其分为对照组与观察组,每组各有患者27例.对照组患者治疗方案为口服泼尼松联合甲氨蝶呤,观察组患者则在常规治疗基础上联合羟氯喹治疗.对比2组治疗前后的SLEDAI评分(系统性红斑狼疮活动评分)、ALB和C3水平以及2组的不适症状发生情况.结果 2组治疗前的SLEDAI分值、ALB与C3水平相仿(P〉0.05)差异无统计学意义;经治疗后,2组各项指标均出现不同程度改善,且以观察组改善更显著(P〈0.05)差异有统计学意义.在不适症状方面,2组治疗期间均有不适症状发生,但对比不明显,差异无统计学意义(P〉0.05).结论对系统性红斑狼疮患者实施羟氯喹治疗有确切疗效,且安全可靠,值得普及应用. “,”Objective To investigate the clinical effectiveness of systemic lupus erythematosus hydroxychloroquine treatment in clinical application. Methods Randomly selected in our hospital from 2012 ~2014 years in patients with systemic lupus erythematosus in 54 cases,according to the different treatment methods will be divided into control group and observation group,each group has 27 patients.Patients in the control group treatment for oral prednisone and methotrexate,patients in the observation group was on the basis of routine treatment combined withhydroxychloroquine treatment. Comparing the 2 groups before and after treatmentSLEDAI score,ALB and C3 levels and a 2 set of discomfort symptoms. Results The 2 groups before treatment,SLEDAI scorelALB and C3 levels were similar (P;〉0.05);after the treatment,2 groups of indexes appeared different degree of improvement,and by the observation group improved more significantly (P〈0.05). In thetmcomfortable symptoms,during the 2 groups have symptoms,but the contrastdifference is not significant (P〉0.05). Conclusion The implementation of curative effect of hydroxychloroquine treatment on the patients with systemic lupus erythematosus,safe and reliable,it is worth popularization and application.