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目的探讨经阴道小卵泡穿刺抽吸对多囊卵巢综合征(PCOS)不孕患者卵巢窦卵泡计数及妊娠的影响。方法将80例行人绝经期促性腺激素(hMG)促排卵的PCOS患者随机分为二组,观察组40例,于卵泡直径达8~10mm时行经阴道小卵泡穿刺;对照组40例,仅行常规促排卵,连续观察6个月,观察穿刺治疗前后性激素FSH、LH、T水平的变化,比较二组患者卵巢窦卵泡计数及妊娠情况。结果观察组与治疗前比较,21例患者的血清LH/FSH、T降低,其中5例血清LH/FSH、T恢复正常,穿刺前后LH/FSH、T有统计学差异(P<0.01),对照组变化不明显,观察组40例患者卵巢基础窦卵泡计数降至10个/卵巢以下,无1例发生卵巢过度刺激综合征(OHSS),6个月内16例妊娠;对照组患者的血清性激素水平无明显变化,卵巢基础窦卵泡计数仍为10个/卵巢以上,发生OHSS者1例,6个月内仅3例妊娠。结论常规治疗无效的PCOS不孕患者,经阴道行小卵泡穿刺抽吸为有效治疗途径。
Objective To investigate the effect of transvaginal small follicle aspiration on ovarian antral follicle count and pregnancy in patients with polycystic ovary syndrome (PCOS) infertility. Methods Eighty PCOS patients with ovulation induced by human menopausal gonadotrophin (hMG) were randomly divided into two groups. The observation group consisted of 40 cases. Transvaginal follicular puncture was performed when the follicle diameter was 8 ~ 10mm. The control group, 40 cases, Regular ovulation induction, continuous observation of 6 months, observed before and after puncture treatment of sex hormones FSH, LH, T levels were compared between two groups of patients with ovarian antral follicle count and pregnancy. Results The serum levels of LH / FSH and T in 21 patients were lower in observation group than those in the control group. Serum LH / FSH and T were normal in 5 cases and LH / FSH and T in the two groups were significantly different (P <0.01) The change of group was not obvious. In 40 cases of observation group, the count of ovarian basal antral follicle decreased to below 10 / ovary, none of them had ovarian hyperstimulation syndrome (OHSS) and 16 cases of pregnancy within 6 months. In the control group, serum sex hormone No significant changes in the level of ovarian basal antral follicle count is still above 10 / ovarian, OHSS occurred in 1 case, 6 months only 3 cases of pregnancy. Conclusion Invalid routine PCOS infertility patients, transvaginal follicular aspiration therapy is an effective treatment.