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作者对141例慢性B淋巴细胞白血病(B-CLL)患者进行外周血细胞染色体分析研究,男性74例,女性67例。年龄33～90岁(平均69岁)。临床随访时间最短12个月,最长25年。最常见的细胞膜表面表型是表面免疫球蛋白(SIg)MDK(30例),MDλ(28例),MK(24例)和Mλ(13例)。95例为表面κ轻链表达和44例为表面λ轻链表达。30/133例(32.5％)的FMC7阳性细胞>10％。19/133例(14.5％)有血清和/或尿副蛋白。初诊时88例为AO期,18例为AI期。18例为AⅡ期,11例为B期和6例为C期。44例(31％)疾病呈进展性,42例(30％)在研究期间死亡,其中21例(50％)死亡与CLL相关(死于感染或骨髓衰竭)。65
The author of 141 cases of chronic B-cell lymphocytic leukemia (B-CLL) patients with peripheral blood cell chromosome analysis of 74 males and 67 females. Age 33 to 90 years (mean 69 years). The shortest clinical follow-up period of 12 months, up to 25 years. The most common cell surface phenotypes were surface immunoglobulin (SIg) MDK (30 cases), MDλ (28 cases), MK (24 cases) and Mλ (13 cases). 95 cases were surface κ light chain expression and 44 cases were surface λ light chain expression. 30/133 (32.5%) FMC7 positive cells> 10%. 19/133 (14.5%) had serum and / or urine paraprotein. 88 cases were newly diagnosed as AO stage, 18 cases were AI stage. 18 cases were stage AII, 11 cases were stage B and 6 cases were stage C. Forty-four (31%) of the patients developed progressive disease, and 42 (30%) died during the study. Twenty-one (50%) of these deaths were associated with CLL (death from infection or bone marrow failure). 65