论文部分内容阅读
由甲基乙基丙二酸与l-薄荷醇的单酯化反应产物(Ⅰ)经酰氯(Ⅱ)转变为酰胺(Ⅲ),(Ⅲ)经皂化得到部分光学活性的甲基乙基丙二酸氢酰胺(Ⅳ),(Ⅳ)经Hoffmann降解得到部分光学活性的2-甲基-2-氨基丁酸(V).
The monoesterification reaction product (Ⅰ) of methyl ethylmalonic acid and l-menthol is converted to amide (III) by acid chloride (II), and the partially optically active methyl ethylpropane di Hydrogen amides (IV) and (IV) are partially degraded by Hoffmann to give 2-methyl-2-aminobutyric acid (V) which is partially optically active.