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目的:探讨重度子痫前期患者血清中NF-KB的表达及炎症细胞因子的变化。方法:选取2014年1月至2017年1月在解放军第202医院产科住院分娩的孕晚期重度子痫前期的孕产妇40例,随机选取同期的晚期妊娠正常孕产妇40例。采用ELISA法检测分娩前血清中NF-KB及其炎症细胞因子的水平。结果:子痫前期患者血清中NF-KB、CRP、IL-6、IL-12水平均显著高于高于对照组(P<0.01)。结论:子痫前期患者血清中NF-KB、CRP、IL-6、IL-12浓度较正常晚期妊娠妇女升高。提示:子痫前期的发生与炎症密切相关。
Objective: To investigate the expression of NF-κB in serum of patients with severe preeclampsia and the changes of inflammatory cytokines. Methods: From January 2014 to January 2017, 40 pregnant women with severe preeclampsia who were delivered in the obstetric department of the 202 Hospital of PLA from March 2014 to January 2017 were selected and 40 normal pregnant women in the late pregnancy were randomly selected. Serum levels of NF-κB and its inflammatory cytokines were measured by ELISA before delivery. Results: The serum levels of NF-KB, CRP, IL-6 and IL-12 in preeclampsia patients were significantly higher than those in the control group (P <0.01). Conclusion: Serum levels of NF-KB, CRP, IL-6 and IL-12 in preeclampsia patients are higher than those in normal late pregnant women. Tip: The occurrence of preeclampsia and inflammation are closely related.