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自Waksman发现链霉素(下简称SM)迄今已三十余年。近年因临床应用更为广泛,中毒症状的观察也较详细,除慢性听神经毒性和过敏反应外,SM还有神经肌肉阻滞和神经节阻滞作用。早年Molitor等曾观察一些恒温动物用致死量的SM后皆死于呼吸麻痹,两栖动物的急性中毒症状是全身瘫痪和呼吸停止。这一问题,当时并未引起注意。直至1957年Vital,Brazil和Corrado重新系统地探索了上述现象,发现SM有类似Mg~(2+)产生的神经
Since Waksman found that streptomycin (hereinafter referred to as SM) so far more than thirty years. In recent years because of clinical application is more extensive, the observation of poisoning symptoms are more detailed, in addition to chronic auditory neurotoxicity and allergic reactions, SM also neuromuscular block and ganglion block. In the early years, Molitor et al. Observed that some warm-blooded animals died of respiratory paralysis with a lethal dose of SM. The symptoms of amphibian acute poisoning were general paralysis and cessation of respiration. This issue did not draw attention at that time. Until 1957, Vital, Brazil and Corrado systematically explored the above phenomenon and found that SM has similar Mg 2+ -producing nerves