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六水哌嗪是制备磷酸哌嗪、海群生、脑益嗪、利福平等许多药物的中间体。对本品的含量测定一般采用以苦味酸作沉淀剂,将其转化为苦味酸哌嗪(C_4H_(10)N_2·2C_6H_3O_7N_3),然后经过滤、洗涤、干燥至恒重后,称量并计算其含量,手续繁杂、分析时间长,对指导生产颇为不便。为此,我们参考了文献[1],把原重量法改为碱滴定法,即用苦味酸将六水哌嗪沉淀后过滤,再用氢氧化钠标准溶液滴定剩余的苦味酸,分析时间由原来的5
Piperazine hexahydrate is the preparation of piperazine phosphate, sea qun, brain Yizi, rifampicin and many other drug intermediates. The determination of the content of this product is generally used picric acid as a precipitating agent, which is converted to picric acid piperazine (C_4H_ (10) N_2 · 2C_6H_3O_7N_3), and then filtered, washed, dried to constant weight, weighed and calculated Content, complicated procedures, analysis of a long time, to guide the production quite inconvenient. To this end, we refer to the literature [1], the original weight method was changed to alkaline titration, picric acid with piperazine precipitation after precipitation, and then sodium hydroxide standard titration of the remaining picric acid, analysis time from The original 5