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介绍了海藻酸盐水溶液的凝胶化及其临界行为和松弛临界指数n.提出了将凝胶化按高分子的分子链长短分为生长型和交联型两类,前者为无规交联,符合逾渗连接的条件;后者大分子链间交联,不符合无规逾渗连接的条件.介绍了微囊化细胞载体、预成型支架和可注射支架,能够为软骨细胞提供良好的三维生长环境;通过LbL、二价离子交联等自组装技术,海藻酸能够实现对多种类型药物的包埋和控释.
The gelation of Alginate aqueous solution and its critical behavior and critical relaxation index (n) are introduced. It is proposed that the gelation should be divided into two types: growth type and crosslink type according to the molecular chain length of the polymer. The former is random crosslinked , In line with the conditions of percolation connection; the latter macromolecular chains cross-linked, does not meet the conditions of the random percolation connection introduced microencapsulated cell carriers, pre-scaffolds and injectable scaffolds, can provide a good chondrocyte Three-dimensional growth environment; through the LbL, bivalent ion crosslinking and other self-assembly technology, alginate can achieve a variety of types of drug embedding and controlled release.