目的:探讨年轻子宫颈鳞癌患者腹腔镜手术并结肠旁沟卵巢侧面移位术后(LOT)卵巢内分泌功能和并发症及新辅助动脉化疗(NACT)在宫颈鳞癌患者卵巢保护中的作用。方法:选取石河子大学医学院第一附属医院妇科2005年4月～2007年10月、腹腔镜宫颈鳞癌手术时行LOT者19例(术前NACT7例)及卵巢原位保留的3例共22例早期年轻(手术年龄<45岁)子宫颈鳞癌患者为研究对象,测定患者手术前后血清女性激素水平、B超检查及患者填写围绝经期综合征量表,调查术后卵巢内分泌功能及并发症的情况。结果:LOT未放疗组术后女性激素水平、Kupperman评分与术前并无显著性差异(P>0.05);LOT放疗组FSH、LH、Kupperman评分高于未放疗组(P<0.05),但显著低于原位保留放疗组(P<0.05);术前行NACT再行手术及LOT的7例,完全缓解(CR)2例,部分缓解(PR)4例,稳定(NC)1例,有效率(CR+PR)85.7%;19例LOT患者随访中无1例发生转移,1例术后1个月盆腔积液,1例术后间歇性右侧移位卵巢部位轻微疼痛。结论:LOT是保留年轻宫颈鳞癌患者卵巢功能有效的方法;卵巢移位后减少了放疗对卵巢内分泌功能的损害,但放疗对移位卵巢还是有一定影响,并不能完全避开放射线的照射;新辅助动脉化疗使部分中、晚期患者保留卵巢成为可能,值得推广;LOT术后并发症发生率较低。 Objective: To investigate the role of ovarian endocrine function and complications and neoadjuvant arterial chemotherapy (NACT) in ovarian protection of patients with cervical squamous cell carcinoma after laparoscopic surgery and lateral paracentesis of the colon. METHODS: From April 2005 to October 2007, the first affiliated hospital of Shihezi University School of Medicine was selected, and 19 cases of LOT were performed during laparoscopic surgery for cervical squamous carcinoma (n = 7 preoperative NACT) and 3 cases of in situ preservation of the ovary. 22 Cases of early-stage young (surgical age <45 years) patients with cervical squamous cell carcinoma as the study object, determination of serum levels of female hormones before and after surgery, B-ultrasound and patients fill in perimenopausal syndrome scale, investigation of ovarian endocrine function and concurrent postoperative Condition. RESULTS: There was no significant difference in female hormone levels and Kupperman scores before and after LOT radiation therapy (P>0.05). FSH, LH, and Kupperman scores were significantly higher in the LOT radiation group than in the non-radiotherapy group (P<0.05). Less than in situ retained radiotherapy group (P<0.05); NACT reoperation and LOT before surgery in 7 cases, complete remission (CR) in 2 cases, partial remission (PR) in 4 cases, stable (NC) in 1 case, Efficiency (CR+PR) was 85.7%. None of the 19 LOT patients had metastasis during follow-up. One patient had pelvic effusion 1 month postoperatively, and 1 patient had intermittent pain in the right-shifted ovary. Conclusion: LOT is an effective method to retain ovarian function in young patients with cervical squamous cell carcinoma. Ovariectomy reduced the damage of ovarian endocrine function after radiotherapy, but radiotherapy still has an effect on transposition of ovary, and can not completely avoid open ray irradiation; Neo-adjuvant arterial chemotherapy has made it possible to preserve ovaries in some patients in the middle and late stages, and it is worth promoting. The complication rate after LOT is low.