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目的:观察不同血糖浓度对大鼠心肌缺血再灌注损伤的影响.方法:结扎大鼠冠状动脉左前降支(LAD)30min,复灌1h后复制出大鼠心肌缺血再灌注损伤(MIRI)模型,观察不同血糖水平(高血糖、低血糖)对大鼠心肌梗死面积及复灌30min后Ⅱ导联心电图(ECG)QRS波、ST、心率及心律失常的影响.结果:与对照组比较,高血糖组、低血糖组大鼠心梗面积明显增加,差异有显著性(P<0.05或P<0.01),ECG ST段明显抬高,心律失常发生次数明显增加,差异有显著性(P<0.05或P<0.01),钙拮抗剂维拉帕米能明显缩小大鼠心梗面积、抑制ECG ST段抬高,并减少心律失常发生次数,差异有显著性(P<0.05或P<0.01).结论:高血糖及低血糖均可加重MIR损伤程度.
Objective: To observe the effect of different blood glucose concentrations on the myocardial ischemia-reperfusion injury in rats.Methods: The left anterior descending (LAD) of the coronary artery was ligated for 30 minutes in rats, and the myocardial ischemia-reperfusion injury (MIRI) Model was established to observe the effects of different blood glucose levels (hyperglycemia and hypoglycemia) on myocardial infarct size and electrocardiogram (ECG) QRS wave, ST, heart rate and arrhythmia in rats after 30min reperfusion.Results: Compared with the control group, The myocardial infarction area of hyperglycemia group and hypoglycemia group were significantly increased, the difference was significant (P <0.05 or P <0.01), ECG ST segment was significantly elevated, the number of arrhythmia was significantly increased, the difference was significant (P < 0.05 or P <0.01). The verapamil, a calcium antagonist, significantly reduced myocardial infarct size, inhibited ECG ST segment elevation and decreased the incidence of arrhythmia (P <0.05 or P <0.01) Conclusions: Both hyperglycemia and hypoglycemia may aggravate the degree of MIR injury.