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一、抗氯喹恶性疟的概念能在正常杀灭或抑制其同种疟原虫增殖的氯喹浓度中继续存活并繁殖的恶性疟原虫称为抗氮喹株恶性疟原虫,由它引起的疟疾即为抗氯喹恶性疟。这些抗性株的出现,目前认为是由于核基因自发性突变,并在药物作用下自然选择的结果。同位素标记的实验表明,感染疟原虫的红细胞对氯喹有一浓集机制,而感染抗氯喹株恶性疟原虫的病人的红细胞浓集氯喹的浓
First, the concept of anti-chloroquine falciparum malaria Plasmodium falciparum, which continues to survive and reproduce in the presence of chloroquine, normally killing or inhibiting the proliferation of the same species of Plasmodium, is known as the anti-NQQ Plasmodium falciparum and the malaria caused by it is Anti-chloroquine falciparum malaria. The emergence of these resistant strains is now believed to be due to spontaneous mutations in the nuclear gene and the result of natural selection under the action of the drug. Isotope-labeled experiments show that erythrocytes infected with Plasmodium have a concentration mechanism of chloroquine, whereas those infected with chloroquine-resistant Plasmodium falciparum erythrocytes concentrate chloroquine enriched