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目的：研究化学损毁外周交感神经对皮肤电导及表皮缝隙连接的影响。方法：给大鼠、小鼠腹腔注射６－羟多巴胺，测定皮肤电导并用电镜形态计量学方法研究表皮缝隙连接的改变。结果：经６－羟多巴胺处理后，大鼠膀胱经与对照皮肤电导差异减小；小鼠皮肤电导下降，其表皮缝隙连接的面数密度、平均外径及数密度均低于对照组。结论：儿茶酚胺类物质与表皮缝隙连接及皮肤电导之间存在密切联系。
OBJECTIVE: To study the effect of chemical damaged peripheral sympathetic nerve on skin conductance and epidermal gap junction. Methods: Rats and mice were injected intraperitoneally with 6-hydroxydopamine. Skin conductance was measured and electron microscopy histomorphometry was used to study the changes of epidermal gap junction. Results: After 6-hydroxydopamine treatment, the difference of conductance between the bladder and the control skin decreased. The skin conductivity of the mice decreased. The number density, average outer diameter and number density of the epidermal gap junction were all lower than those of the control group. Conclusions: There is a close relationship between catecholamines and epidermal gap junction and skin conductance.