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目的:研究西他沙星(sitafloxacin hydrate)对小鼠感染模型耐甲氧西林金黄色葡萄球菌肺炎的保护作用。方法:利用气管注射耐甲氧西林金葡菌,建立小鼠肺部感染的动物模型,并在此基础上,通过腹腔给药的方式,检测不同剂量的西他沙星给药后小鼠体质量的改变及其肺部病理学的变化。结果:小鼠经气管注射耐甲氧西林金葡菌3 d后,小鼠体质量减轻,其肺脏发生明显的病理学改变;采用西他沙星可有效减缓小鼠体质量及其肺脏的病理学变化。结论:西他沙星可以有效地抑制耐甲氧西林金葡菌引发的感染,具有良好地保护作用。
Objective: To study the protective effect of sitafloxacin hydrate against methicillin-resistant Staphylococcus aureus pneumonia in mouse model of infection. Methods: Animal models of pulmonary infection in mice were established by tracheal injection of S. aureus, and on the basis of this, by intraperitoneal administration, different doses of sitaxacin were administered to mice Quality changes and changes in their lung pathology. Results: After mice were intratracheally inoculated with methicillin-resistant Staphylococcus aureus for 3 days, the body weight of the mice was reduced and the pathological changes of the lungs were observed. Sitaxacin was effective in alleviating the body weight and lung disease in mice Neo-Confucianism changes. Conclusion: Sitafloxacin can effectively inhibit the infection caused by methicillin-resistant Staphylococcus aureus and has a good protective effect.