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用酶联免疫法检测了25例儿童急性白血病（A组：8例，伴中枢神经系统白血病，B组：17例，不伴中枢神经系统白血病）脑脊液（CSF）中肿瘤坏死因子（TNF）及其与CSF各化验指标的相关性，结果示：A组病人CSF中TNF为10．06士13．50ng／ml，较B组（1．1士0．42ng／ml）升高，差异有显著意义（P＜0．01），CSF中TNF的升高与CSF细胞数及蛋白呈正相关（r=0．6807，0．6764，P＜0．05），与CSF糖无相关性，A组中三例病人动态观察的结果示随治疗后症状改善，TNF也下降。
Tumor necrosis factor (TNF) levels in cerebrospinal fluid (CSF) of 25 children with acute leukemia (group A: 8 with central nervous system leukemia, group B: 17 without central nervous system leukemia) were detected by enzyme-linked immunosorbent assay The correlation between CSF and various laboratory indexes showed that the CSF TNF in group A was 10.06 ± 13.50ng / ml, which was significantly higher than that in group B (1.1 ± 0.42ng / ml), the difference was significant (P <0.01). The increase of TNF in CSF was positively correlated with the number of CSF cells and protein (r = 0.6807, 0.6764, P <0.05) The results of three patients in the dynamic observation showed that TNF also decreased with the improvement of symptoms after treatment.