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已知血小板糖蛋白Ⅱ_b/Ⅲ_a(CpⅡ_b-Ⅲ_a)作为一种膜受体与急性冠心病的发病机理有关,但未见它与青年人卒中关系的研究报道。作者通过一个基于人群的病例对照研究,对GpⅢ_a的P1A2多态性与青年妇女脑梗死的关系进行了探讨。 病例组65例,平均年龄15～44岁的妇女,均为美国Baltimore-Washington地区经神经科医生诊断的首次脑梗死出院患者:分为两个亚组:①已明确患有很可能导致卒中的病因的患者18例,这些病因包括动脉硬化、心源性栓塞、非动脉硬化性血管病、血液疾患等。②未检查出上述病因的患者47例。对照组122例为无卒中史妇女,在年龄分布、居住地区与病例组相同。 每个对象均采血测定P1A2等位基因和胆固醇水平,并面对面调查其年龄、种族、有无高血压、糖尿病、高胆固醇血症以及吸烟状况等已知的卒中危险因素。
Platelet glycoprotein Ⅱ_b / Ⅲ_a (CpⅡ_b-Ⅲ_a) is known to be involved in the pathogenesis of acute coronary heart disease as a membrane receptor, but it has not been reported in studies of stroke in young people. Through a population-based case-control study, we investigated the association of GpIII-a P1A2 polymorphism with cerebral infarction in young women. In the case group, 65 women with a mean age of 15-44 years were all discharged from their first cerebral infarction diagnosed by neurologists in the Baltimore-Washington area of the United States: they were divided into two subgroups: (1) those with definite risk of developing stroke Etiological patients in 18 cases, these causes include atherosclerosis, cardioembolism, non-arteriosclerotic vascular disease, blood disorders. ② not detected in 47 patients with the above etiology. The control group of 122 cases without history of stroke in women, age distribution, living area and the same case group. Blood samples were collected from each subject for determination of the P1A2 allele and cholesterol levels and face-to-face investigation of known stroke risk factors such as age, race, presence of hypertension, diabetes, hypercholesterolemia, and smoking status.