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每日给大鼠注射醋酸去氧皮质酮(DOCA),连续5,10,20或30天,血清钾水平约降低25％,在此期间血清钠浓度不变。趾长伸肌与比目鱼肌钾浓度明显降低,钠浓度增加。随着电解质浓度的这些变化,两块肌肉的静息膜电位在体时呈超极化,而离体时,随外界钾浓度的降低而表现出去极化现象。肌肉线粒体受损。趾长伸肌中的受损程度较比目鱼肌中的严重。损伤程度与使用醋酸去氧皮质酮的时期长短有关。
The rats were injected with deoxycorticosterone acetate (DOCA) daily for 5, 10, 20 or 30 days, serum potassium levels were reduced by approximately 25%, and serum sodium concentrations remained unchanged during this period. The potassium concentration of long extensor muscles and soleus muscles decreased significantly, and sodium concentration increased. With these changes in electrolyte concentration, the resting membrane potential of the two muscles was hyperpolarized at body time, and the out-polarization phenomenon was exhibited as the external potassium concentration decreased. Damage to muscle mitochondria. The extent of damage in the long extensor digitorum tendon is more severe than in the soleus muscle. The degree of damage is related to the length of the period of use of deoxycorticosterone acetate.