【摘 要】
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Despite impressive survival benefits with immunotherapy in patients with various solid tumors,the full potential of these agents in prostate cancer has yet to be realized.Sipuleucel-T demonstrated a survival benefit in this population,indicating that pros
【机 构】
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Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA;Genitourinary Malignancies B
论文部分内容阅读
Despite impressive survival benefits with immunotherapy in patients with various solid tumors,the full potential of these agents in prostate cancer has yet to be realized.Sipuleucel-T demonstrated a survival benefit in this population,indicating that prostate cancer is an immunoresponsive disease;however,these results have not been matched by other agents.A large trial with ipilimumab in prostate cancer failed to meet its primary objective,and small trials with PD-1/PD-L1 inhibitors did not yield a significant improvement in overall response.However,several late-stage clinical trials are underway with other vaccines in prostate cancer.Reports of clinical benefit with immunotherapies,particularly when used in combination or a select population,have provided the framework to develop sound clinical trials.Understanding immunogenic modulation,antigen spread,biomarkers,and DNA-repair defects will also help mold future strategies.Through rational patient selection and evidence-based combination approaches,patients with prostate cancer may soon derive durable survival benefits with immunotherapies.
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