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本文就１９６６～１９９３年２１个省市分离的２１８株Ａ、Ｂ和Ｃ群脑膜炎奈瑟氏菌（Ｎｍ）对７种常用抗菌药物的敏感性进行了监测。在１０８株Ａ群Ｎｍ中２０株（１８．５％）对ＳＭＺ耐药，其中１７．３％的病人菌株，２１．２％的带菌者菌株耐药；３１株（２８．７％）对ＡＳＰ耐药。在１０１株Ｂ群Ｎｍ中４０株（３９．６％对ＳＭＺ耐药。其中４３．３％的病人菌株和３４．１％的带菌者菌株耐药，１７株（１６．８％）对ＡＳＰ，１０株（９．９％）对ＣＦ耐药。在９株Ｃ群Ｎｍ中５株对ＳＭＺ，２株对ＡＳＰ耐药。未发现Ｎｍ对Ｃｈｌ耐药。实验结果提示我们今后在流脑治疗和化学预防上应加强Ｎｍ对抗菌药物敏感性的监测，这有助于提高这些药物对流脑防治的效果。
In this paper, 218 strains of group A, B and C Neisseria meningitidis (Nm) isolated from 21 provinces and municipalities from 1966 to 1993 were used to monitor the sensitivity of seven common antibacterials. Twenty (18.5%) of 108 strains of A group Nm were resistant to SMZ, of which 17.3% were resistant to the strain, 21.2% were resistant to the strain; 31 (28.7%) were resistant to ASP Resistance. 40 (39.6%) were resistant to SMZ in 101 B-group Nm strains, of which 43.3% were resistant to drug-resistant strains and 34.1% were carriers, 17 (16.8% Ten strains (9.9%) were resistant to CF. Five strains of SMZ and two strains were resistant to ASP in 9 strains of C group Nm.Nm was not found to be resistant to Chl.The results suggest that in the future, Chemical prevention should strengthen the Nm on the monitoring of antimicrobial susceptibility, which helps to improve the effectiveness of these drugs on the prevention and treatment of meningitis.