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作者对38例严重、有生命威胁的需氧、兼性及厌氧菌合并感染的成人患者用注射克林达霉素和庆大霉素治疗。男20例,女18例。年龄17～84岁。4例肺炎合并脓胸,15例皮肤、软组织及/或骨感染,19例与消化道或妇科病有关的腹腔内感染。其中9例发生菌血症,4例血中有多种细菌。开始时用克林达霉素静注,其剂量在1例为300毫克,每8小时1次;28例用600毫克,每8小时1次;9例用900毫克,每8或12小时1次。在疗程中剂量偶有改变或改用肌注。庆大霉素开始时一般用60或80毫克,每8小时1次,静脉或肌肉注射。剂量随体重或肾功能降低而作调整。33例治疗前血清肌酐在1.4毫克/100毫升或以下者,维持剂量为3.34±0.71毫克/公斤/日,5例为1.6～2.1毫克/100毫升者,剂量为2.92±0.91毫克/公斤/日,疗程7～40天。临床研究结果:4例肺炎合并脓胸患者中3例治愈,1例病情改善,但因出现皮疹而需改变治疗方案。皮肤、软组织与骨感染的15例中,14例治愈(2例有菌血症),1例无效。9例腹腔内感染患者,7
The authors treated 38 adult patients with severe, life-threatening aerobic, facultative and anaerobic infections with injection of clindamycin and gentamicin. 20 males and 18 females. Age 17 to 84 years old. 4 cases of pneumonia complicated with empyema, 15 cases of skin, soft tissue and / or bone infections, 19 cases of intra-abdominal infections associated with digestive tract or gynecological diseases. Among them, 9 cases had bacteremia and 4 cases had many kinds of bacteria in blood. Initially with clindamycin intravenous injection, the dose of 300 mg in 1 case, once every 8 hours; 28 cases with 600 mg once every 8 hours; 9 cases with 900 mg, every 8 or 12 hours 1 Times. In the treatment of occasional dose changes or use of intramuscular injection. Gentamicin at the start with 60 or 80 mg, once every 8 hours, intravenous or intramuscular injection. Dose with weight or renal function to make adjustments. Thirty patients with a serum creatinine of 1.4 mg / 100 mL or less before treatment had a maintenance dose of 3.34 ± 0.71 mg / kg / day, 5 patients had 1.6 to 2.1 mg / 100 mL, and a dose of 2.92 ± 0.91 mg / kg / day , Treatment for 7 to 40 days. Clinical Study Results: Three of four patients with pneumonia complicated with empyema were cured, one with improved disease, but the treatment regimen needed to be changed because of a rash. Of 15 cases of skin, soft tissue and bone infections, 14 were cured (2 with bacteremia) and 1 was ineffective. Nine patients with intra-abdominal infection, 7