近年维生素A缺乏和一些上皮源性癌肿的关系已引起人们的极大重视。实验证明,维生素A缺乏时,动物呼吸道、皮肤、膀胱及结肠对化学诱癌剂有极高的敏感性。当饮食中加入少量棕榈酸视黄醇酯(Retinyl acetate),就能降底这种敏感性。如大剂量应用天然维甲类,可以预防肺、小肠、胃、食管、乳腺、气管及支气管癌肿的发生。所以维生素A及其衍生物已成为一组在癌肿预防中具有较大潜力的药物。 Fujimaki1926年首次报道用缺乏维生素A饲料喂 In recent years, the relationship between vitamin A deficiency and some epithelial cancers has attracted great attention. Experiments have shown that in the absence of vitamin A, respiratory tract, skin, bladder, and colon have a high sensitivity to chemical carcinogens. This sensitivity can be reduced by adding a small amount of Retinyl acetate to the diet. Such as high-dose application of natural retinoids, can prevent lung, small intestine, stomach, esophagus, breast, trachea and bronchial cancer. Therefore, vitamin A and its derivatives have become a group of drugs that have great potential for cancer prevention. Fujimaki first reported in 1926 with a lack of vitamin A feed