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心钠素是贮存于心房细胞内的一种特殊颗粒,释放于血中成为具有生物活性的激素,它能作用于肾、血管平滑肌等靶器官,产生利尿、利钠及降压作用。近年来用放射免疫方法已能测定人体心钠素浓度,本文观察了不同年龄健康儿及心脏病儿心钠素浓度的变化。163例健康受检者,男94例,女69例,年龄从0～16岁,测定发现在生后2～4,天心钠素(129～356Pg/ml,平均227,P<0.001)明显高于其它年龄期。其它年龄期心钠素无显著差异(2～109pg/ml,平均47)。
Atrial natriuretic peptide (atrial natriuretic peptide) is a special type of granules stored in atrial cells. It is released into the blood and becomes a bioactive hormone. It acts on target organs such as kidney and vascular smooth muscle to produce diuretic, sodium and antihypertensive effects. In recent years, the method of radioimmunoassay has been able to determine the concentration of human atrial natriuretic peptide, this article observed the changes of atrial natriuretic peptide in healthy children and heart disease children of different ages. 163 cases of healthy subjects, 94 males and 69 females, aged from 0 to 16 years old, measured in the postnatal 2 to 4, Tian atrial natriuretic peptide (129 ~ 356Pg / ml, an average of 227, P <0.001) was significantly higher In other age groups. Other age atrial natriuretic no significant difference (2 ~ 109pg / ml, an average of 47).