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目的 比较小剂量抗抑郁药物盐酸帕罗西汀和匹维溴胺与单独应用匹维溴胺治疗肠易激综合征的疗效。方法 将 70例符合罗马Ⅰ诊断标准的肠易激综合征患者随机分为两组 :治疗组 (简称P +P组 ) ,3 4例应用盐酸帕罗西汀 (每日一次 ,每次口服 10mg)加匹维溴胺 (每日三次 ,每次口服 5 0mg) ;对照组 (简称P组 ) ,应用匹维溴胺 ,疗程均为 12周。结果 在胃肠道症状方面 ,P +P组对腹痛程度和腹痛天数、腹胀程度和腹胀天数及大便次数的改善优于P组 ,而在大便性状改善方面两组间则无差异 ;在精神和躯体症状方面 ,P +P组对焦虑及腰背痛症状的改善优于P组 ,其它如抑郁、不愉快、疲惫及头痛改善方面两组间也无差异。结论 小剂量盐酸帕罗西汀加匹维溴胺能明显改善肠易激综合征患者的胃肠道及部分精神和躯体症状 ,是肠易激综合征药物治疗的一种有效方法。
Objective To compare the curative effect of paroxetine hydrochloride and piroxicam on the low dose antipsychotic drug pirfenidone alone in the treatment of irritable bowel syndrome. Methods Seventy patients with irritable bowel syndrome who meet the diagnostic criteria of Rome Ⅰ were randomly divided into two groups: treatment group (P + P group), 34 cases treated with paroxetine hydrochloride (once daily, 10 mg per day) Pivaradamine (three times a day, orally 50mg); control group (referred to as P group), the application of pivalveriptyline, treatment for 12 weeks. Results In the gastrointestinal tract, the P + P group was superior to the P group in the degree of abdominal pain and the number of days of abdominal pain, the degree of bloating, the number of days of bloating and the number of stools, but no difference in the improvement of stool performance between the two groups. In somatic symptoms, P + P improved symptoms of anxiety and lower back pain better than those in P, and there was no difference between the two groups in terms of depression, unpleasantness, fatigue and headache. Conclusion Low-dose paroxetine hydrochloride and pyridaben hydrochloride can significantly improve the gastrointestinal tract and some mental and physical symptoms in patients with irritable bowel syndrome. It is an effective method for drug treatment of irritable bowel syndrome.