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Nicotinic and muscarinic receptors are distinctively different, and belong to ion channel-gated and GTP binding protein-coupled receptor superfamily respectively. But they have the same endogenous agonist acetylcholine (ACh), and they are the 2 types of cholinergic receptors and mediate the physiologic functions of cholinergic nervous system. The innervation and regulatory effects between nicotinic and muscarinic receptors have been studied extensively in peripheral nervous system (PNS). The functions of muscarinic receptors in the tissues innervated by the parasympathetic cholinergic postfibers, can be modulated by
Nicotinic and muscarinic receptors are distinctively different, and belong to ion channel-gated and GTP binding protein-coupled receptor superfamily respectively. But they have the same endogenous agonist acetylcholine (ACh), and they are the 2 types of cholinergic receptors and mediate the physiologic The functions of muscarinic receptors in the tissues innervated by the parasympathetic cholinergic postfibers, can be modulated by