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目的探讨长期低剂量接触苯系物对加油站职工健康的影响。方法采用气相色谱-质谱法检测南宁市12个加油站内加油区和对照区空气中苯系物的浓度,对相应区域的暴露组(n=202)与对照组(n=50)职工使用问卷调查工龄、吸烟及饮酒等基本情况,并采集静脉血检测血清总超氧化物歧化酶(T-SOD)、丙二醛(MDA),谷胱甘肽(GSH)和8-羟基脱氧鸟苷(8-OHdG)含量。结果加油区空气中苯、甲苯,乙苯,间、对、邻二甲苯的浓度均高于对照区,差异均有统计学意义(P<0.001);暴露组血清T-SOD活力和GSH含量低于对照组,血清MDA和8-OHdG含量高于对照组,差异均有统计学意义(P<0.05)。结论与对照区比较,加油区职工暴露于较高苯系物浓度;长期低浓度苯系物暴露可能导致加油站职工抗氧化应激能力下降,血清氧化应激产物浓度增加。
Objective To investigate the effects of long-term low-dose exposure of benzene compounds on the health of gas station workers. Methods The concentrations of benzene compounds in the air in the fueling and control areas of 12 gas stations in Nanning were detected by gas chromatography-mass spectrometry (GC-MS). The questionnaire survey of workers in the exposed area (n = 202) and control group (n = 50) Smoking, drinking and other basic information were collected. Venous blood samples were collected for detection of serum total superoxide dismutase (T-SOD), malondialdehyde (MDA), glutathione (GSH) and 8-hydroxydeoxyguanosine -OHdG) content. Results The concentrations of benzene, toluene, ethylbenzene, m-p-xylene and o-xylene were all higher than those in the control zone in the gas-fueled zone, with significant differences between the two groups (P <0.001) In the control group, serum MDA and 8-OHdG levels were significantly higher than those in the control group (P <0.05). Conclusion Compared with the control area, workers in fueling areas are exposed to higher concentrations of benzene compounds. Exposure to long-term low concentrations of benzene compounds may lead to the decrease of antioxidant capacity and the increase of serum oxidative stress products in gas station workers.