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目的分析抗核小体抗体(AnuA)与系统性红斑狼疮(SLE)患者临床特征及其活动性的相关性。方法采用回顾性研究并用调查表的形式收集694例AnuA阳性患者临床资料,并与733例An-uA阴性病人进行比较分析。结果 AnuA与蝶形红斑、光敏感、关节炎、心包炎及狼疮性肾炎的发生相关(P<0.05);AnuA阳性可伴有其他自身抗体及免疫学指标异常出现;AnuA阳性与肾脏损害指标血尿、蛋白尿、管型尿及尿素氮的发生率明显相关(P<0.05);AnuA阳性与系统性红斑狼疮疾病活动性指数(SLEDA I)相关(P<0.05)。结论 AnuA可能是SLE的又一标志性抗体,其检测可用于疾病的早期诊断,有助于SLE疾病活动度、严重程度及狼疮肾炎(lupus nephritis,LN)的判断。
Objective To analyze the correlation between clinical features and activity of anti-nucleosome antibody (AnuA) and systemic lupus erythematosus (SLE). Methods The clinical data of 694 patients with AnuA positive were collected retrospectively and compared with 733 An-uA negative patients. Results AnuA was associated with the occurrence of butterfly erythema, light sensitivity, arthritis, pericarditis and lupus nephritis (P <0.05); AnuA positive was associated with other autoantibodies and immunological abnormalities; AnuA positive and renal damage indicators of hematuria , Proteinuria, tubular urine and urea nitrogen (P <0.05). AnuA positive was associated with SLEDA (P <0.05). Conclusions AnuA may be another landmark antibody of SLE. The detection of AnuA may be used for the early diagnosis of SLE disease and contribute to the judgment of SLE disease activity, severity and lupus nephritis (LN).