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心痛定为钙通道阻断剂,是有效的抗高血压药物,有人主张用以代替血管扩张药治疗高血压,因后者总伴有各种副作用.但是把心痛定作为合理的降压药使用,须进一步了解它的一些重要性能.例如对不同类型高血压的效应如何?未见报导;对静脉张力的作用,报导收缩,扩张或无反应的都有.本文目的为确定心痛定的急性效应,尤其是与剂量的关系,对静脉的作用,对肾上腺素能神经反射的影响,对不同严重程度和不同病因类型高血压的效应.本文研究对象是25～65岁高血压患者45名(男32名,女13名).25名原发性,10名肾血管性和10名患有慢性肾盂肾炎的高血压患者.所有病人实验前两周均不接受治疗,实验期间不用其他药物并接受含有100mEq钠和80mEq钾的标准食品.第一周用安慰剂,舒张压高于100mmHg的病人第七天接受心痛定治疗,均由舌下含服每晨三个胶囊,按双盲法实验.
Heartache as a calcium channel blocker, is an effective antihypertensive drugs, some people advocate for the treatment of hypertension instead of vasodilator, which is always accompanied by a variety of side effects.But nausea as a reasonable use of antihypertensive drugs , To learn more about some of its important properties.For example, the effect on different types of high blood pressure? No reported; on the role of venous tension, reported contraction, expansion or non-response have.This paper aims to determine the acute effect of nifedipine , Especially the relationship with dose, the effects on veins, the effects on adrenergic reflexes, and the effects on hypertension of different severity and different etiologies.This study was conducted on 45 hypertensive patients aged 25-65 years (male 32, 13 females) .25 primary, 10 renovascular and 10 hypertensive patients with chronic pyelonephritis.All patients were not treated for the first two weeks of the experiment and did not receive other medications during the experiment Containing 100 mEq of sodium and 80 mEq of potassium in the first week of placebo, patients with diastolic blood pressure greater than 100mmHg on the seventh day receiving nifedipine treatment, sublingual sublingual morning three capsules by double-blind method.