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目的 研究翼状胬肉组织中细胞间粘附分子1(ICAM-1)的表达水平,探讨ICAM-1在翼状胬肉病理过程中的作用。方法 采用酶联免疫吸附试验法(ELISA)检测28例翼状胬肉患者组织匀浆中的ICAM-1含量,并与正常人结膜组织进行对照。结果 翼状胬肉组织匀浆中ICAM-1含量明显高于正常对照组(P<0.01),进行期组的ICAM-1含量明显高于静止期组(P<0.05)。结论 在翼状胬肉组织中存在ICAM-1异常表达,可能是翼状胬肉发病的重要原因之一。
Objective To study the expression of intercellular adhesion molecule-1 (ICAM-1) in pterygium and to explore the role of ICAM-1 in the pathogenesis of pterygium. Methods The content of ICAM-1 in the tissue homogenate of 28 patients with pterygium was detected by enzyme-linked immunosorbent assay (ELISA) and compared with that of normal human conjunctiva. Results The content of ICAM-1 in the pterygium homogenate was significantly higher than that in the normal control group (P <0.01). The content of ICAM-1 in the phase group was significantly higher than that in the quiescent group (P <0.05). Conclusion The abnormal expression of ICAM-1 in pterygium may be one of the important causes of pterygium.