肿瘤微环境是一种复杂的细胞生态环境,肿瘤细胞与环境共同进化,环境为肿瘤细胞的恶性转变提供支持.在被招募到肿瘤位点的免疫细胞中,巨噬细胞的量最大,且贯穿肿瘤发生发展的各个阶段.动物实验及临床研究均表明巨噬细胞在肿瘤进展中发挥促进作用,并可作为肿瘤联合治疗中的有效靶点.“,”The tumor microenvironment is a complex ecology of cells that evolves with and provides support to tumor cells during the transition to malignancy.Among the immune cells recruited to the tumor site,macrophages are particularly abundant and present at all stages of tumor progression.Clinical studies and experimental mouse models indicate that these macrophages generally play a protumoral role and are attractive targets as part of combination therapy in cancer treatment.