本文综述了近年来四氧化锇催化不对称双羟基化的研究进展。在诸多改进的方法中以铁氰化钾为共氧化剂和以金鸡纳生物碱酯为手性配体的OsO_4催化不对称双羟化为最好,对映体过量一般在90%以上,化学产率为80—95%,我们首次将这个不对称双羟化用于构成植物生长调节剂油菜甾体的双羟基侧链,获得令人满意的结果。 This review summarizes recent advances in the catalytic asymmetric bis-hydroxylation of osmium tetroxide. In many improved methods, potassium ferricyanide as co-oxidant and cinchona alkaloid esters as chiral ligands OsO_4 catalyzed asymmetric dihydroxy is the best, the enantiomeric excess is generally above 90%, chemical production For the first time, this asymmetric dihydroxylation was used to form the bishydroxy side chain of the plant growth regulator rapeseed, giving satisfactory results.