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目的探讨甲状腺功能亢进患者治疗前后血脂和载脂蛋白变化及其临床意义。方法甲状腺功能亢进(GD)的患者46例作为实验组,同时选取46例正常人作为对照组。采用生化分析仪测定所有受试者的血清胆固醇(TC)、甘油三脂(TG)、载脂蛋白APOA1和APOB、高密度脂蛋白胆固醇(HDL-C)的结果 ,并进行比较。结果实验组患者治疗前TC、APOB、HDL-C都明显低于对照组受试者的TC、APOB、HDL-C值,两组比较差异有统计学意义(P<0.05);实验组患者治疗后TC、APOB、HDL-C明显高于实验组患者治疗前TC、APOB、HDL-C值,各项指标趋近于正常,比较差异有统计学意义(P<0.05)。结论 GD患者的血脂和载脂蛋白的含量明显的降低,所以血脂和载脂蛋白的变化可以作为判断GD的有效指标,对病情的观察和治疗都具有重要的意义。
Objective To investigate the changes of blood lipids and apolipoproteins in patients with hyperthyroidism before and after treatment and its clinical significance. Methods Forty-six patients with hyperthyroidism (GD) were selected as experimental group and 46 healthy individuals as control group. The results of serum cholesterol (TC), triglyceride (TG), apolipoproteins APOA1 and APOB, and high density lipoprotein cholesterol (HDL-C) were measured by biochemical analyzer in all subjects and compared. Results The levels of TC, APOB and HDL-C in experimental group before treatment were significantly lower than those in control group (P <0.05). The treatment of experimental group The levels of TC, APOB and HDL-C in TC, APOB and HDL-C before treatment were significantly higher than those in the experimental group, and all the indexes tended to be normal. The difference was statistically significant (P <0.05). Conclusions The levels of lipids and apolipoproteins in patients with GD are obviously decreased. Therefore, the changes of lipids and apolipoproteins may be used as effective indicators to judge GD, which is of great significance for the observation and treatment of the disease.