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目的 :探讨脑选择性降温技术的安全性。 方法 :通过单侧颈总动脉低温灌注法 ,对 10只犬进行了选择性脑部降温。观察了降温过程中生命体征的变化 ,术前及术后血常规、电解质、肝肾功能以及心脏、肝脏酶谱的变化。 结果 :10只犬均实现了选择性脑部降温。脑温最低达 (17.8± 1.8)℃ ,直肠温保持在 (32 .5± 2 .0 )℃以上。4只犬于术后 1～ 3d死亡 ,6只长期存活。降温过程中犬的生命体征有明显改变 ,随温度回升而恢复正常。术后血常规、电解质、肝肾功能、酶谱与术前无显著差异。 结论 :采用动脉内低温灌注 ,可选择性快速降低脑温。降温使脑干心血管中枢功能抑制 ,但经开放椎动脉后可迅速纠正。该技术对全身重要器官生理功能无明显损害。
Objective: To explore the safety of brain selective cooling technique. Methods: Ten dogs were subjected to selective brain cooling by hypothermic perfusion of the unilateral common carotid artery. Changes of vital signs during observation, changes of blood routine, electrolytes, liver and kidney function as well as changes of heart and liver zymogram before and after the operation were observed. Results: All 10 dogs achieved selective brain cooling. The lowest brain temperature (17.8 ± 1.8) ℃, rectal temperature maintained at (32.5 ± 2.0) ℃ above. Four dogs died 1 to 3 days after operation, and 6 long-term survived. During the cooling process, the vital signs of dogs changed significantly and returned to normal with the temperature rising. Postoperative blood, electrolytes, liver and kidney function, zymogram and preoperative no significant difference. Conclusion: Intra-arterial hypothermic perfusion can selectively reduce brain temperature rapidly and selectively. Cooling to inhibit the brainstem cardiovascular central function, but after the opening of the vertebral artery can be quickly corrected. The technology of the vital organs of the body no significant physiological function damage.