论文部分内容阅读
间酚嘧啶双羟萘酸盐——反式-间位[2-(1,4,5,6-四氢-1-甲-2-嘧啶基)-乙烯基]酚4,4′-次甲基双-[3-羟基-2萘酸盐],是国外较新的驱鞭虫药,对人鞭虫病有良好的疗效。上海医药工业研究院合成、杭州第一制药厂试产此药,我们对它进行了毒性和临床观察。小鼠和大鼠每日分别经口给予间酚嘧啶2.3g/kg 和 2g/kg,连续2天,无明显毒性。上述剂量系灌胃最大剂量,故 LD_(50)未能测得。家兔每日给予间酚嘧啶1g/kg,连续2天,亦无明显毒性。家兔12只,分2组,每组6只,分别每日给予间酚嘧啶100mg/kg 和200mg/kg(相当临床剂量10～20倍),连续14天,上述家兔给药前后测定的血象、肝、肾功能均正常。心、肝、脾、肺、肾、肾上腺等脏器病理切片镜检无明显病变。
Naphthopyrimidine pamoate-trans-meta [2- (1,4,5,6-tetrahydro-1 -meth-2-pyrimidinyl) -vinyl] phenol 4,4’- Methyl bis- [3-hydroxy-2 naphthalene acid salt], is a new foreign whip worm medicine, has a good effect on human whipworm disease. Shanghai Pharmaceutical Industry Research Institute synthesis, Hangzhou No. 1 Pharmaceutical Factory trial production of this medicine, we conducted a toxicological and clinical observation. Mice and rats were daily oral administration of m-pyrimidine 2.3g / kg and 2g / kg, for 2 consecutive days, no significant toxicity. Department of the maximum dose of intragastric administration, so LD_ (50) failed to measure. Rabbits administered m-pyrimidine daily 1g / kg, for 2 days, nor obvious toxicity. Twelve rabbits were randomly divided into 2 groups with 6 rats in each group. Mice were given daily 100 mg / kg and 200 mg / kg of m-pyrimidine (equivalent to 10 to 20 times the clinical dose) for 14 consecutive days. Blood, liver, kidney function are normal. Heart, liver, spleen, lung, kidney, adrenal and other organs no obvious pathological examination.