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Objective: To observe the therapeutic effect of high-flux hemodialysis on patients with end-stage renal disease, and to evaluate cardiac function and interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor-α (TNF). -α) effects such as cytokine levels. Methods: Eighty patients with end-stage renal disease who underwent hemodialysis in the Department of Nephrology, Wuyi Hospital of Jiangmen City from June 2016 to June 2018 were enrolled. According to their dialysis methods, they were divided into high-flux dialysis group (40 cases). Low-throughput dialysis group (40 cases). The differences of cardiac function, renal function and IL-6, IL-8 and TNF-α levels between the two groups before and after dialysis were observed. Results: After treatment, LAD,RAD and LVEF in both groups were lower than those before treatment, and LVEF in high throughput dialysis group was lower than that in low throughput dialysis group (t = 9.191, 6.559, P < 0.01). After treatment, SBP,DBP,24hSBP SD and 24hDBP SD in both groups were lower than those before treatment, and those in high throughput dialysis group were lower than those in low flux dialysis group (t=6.217, 10.611, 12.082, 6.564, P < 0.01). There was no difference in cytokine levels between the two groups before treatment. After treatment, I of the two groups of patients was not different from that of the two groups. The levels of IL 6 and TNF-α in high throughput dialysis group were lower than those before treatment, and the levels of IL 6 and GFR α in high throughput dialysis group were lower than those in low flux dialysis group(t=14.245、4.595、6.458, P<0.01). After treatment, BUN,SCr and GFR in high throughput dialysis group were higher than those before treatment, and those in high throughput dialysis group were lower than those in low flux dialysis group (t=7.805, 12.819, P < 0.01). Conclusion: High-flux hemodialysis has a better therapeutic effect on patients with end-stage renal disease, which can significantly improve the heart function of patients and reduce the levels of IL-6 and other cytokines. It has good application value.