细胞恶变的基础是细胞周期调节失控,其中抑癌基因的失活起了重要的作用。研究表明,INK4蛋白家族是最重要的细胞周期调节蛋白,与人类多种肿瘤的发生、发展密切相关,本文对INK4家族各成员与头颈肿瘤关系,包括各蛋白和基因的结构特点、生物学特性及调控机理、在头颈肿瘤中的变异情况和失活机制等进行综述。 Cell malignancy is based on the regulation of the cell cycle out of control, in which tumor suppressor genes play an important role. The research shows that the INK4 protein family is the most important cell cycle regulatory protein and is closely related to the occurrence and development of many human tumors. In this paper, the relationship between INK4 family members and head and neck cancer, including the structural characteristics and biological characteristics of each protein and gene And regulatory mechanisms in the head and neck cancer in the variation and inactivation mechanisms were reviewed.