扩散的乳癌有许多令人痛苦的表现,大概最坏的是骨转移,约60%的病人发生这种情况。溶骨性骨破坏的主要影响是骨疼痛、病理性骨折和高钙血症,后者是骨转移后主要死因之一。遗憾的是,虽然各种细胞毒药物、化疗和激素治疗方案均能暂时缓解,但是进行性骨破坏仍是一主要问题。某些最新的研究提示,二磷酸盐可能对肿瘤诱发的骨再吸收有抑制作用。关于这方面的长期临床试验结果已由芬兰的研究人员作了报 Dilated breast cancer has many painful manifestations, probably the worst is bone metastases, which occurs in about 60% of patients. The main effects of osteolytic bone destruction are bone pain, pathological fractures, and hypercalcemia, the latter being one of the major causes of death after bone metastases. Unfortunately, while various cytotoxic drugs, chemotherapy, and hormone therapy regimens can be temporarily alleviated, progressive bone destruction remains a major problem. Some recent studies suggest that bisphosphonates may have inhibitory effects on tumor-induced bone resorption. The results of long-term clinical trials in this area have been reported by Finnish researchers