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二硫化碳(CS_2)引起糖尿病的作用,至今尚未系统研究过。据Austoni等报导,接触CS_2工人糖尿病发病率高,而Goto等发现,接触CS_2后,葡萄糖耐量无明显差异。芬兰作者极严格地评价了很多组接触CS_2的工人,观察到空腹血糖水平增高无统计学意义,并且血糖水平增高与接触时问长短无关。Abramova(1967)的实验结果说明,在接触CS_2的同时,摄入高碳水化合物饮食可引起糖尿。作者在大鼠慢性试验中(接触CS_2浓度为1.2和2.4 mg/l)观察到,接触动物的葡萄糖耐量曲线与对照组比较无显著差异。3.6 mg/l,浓度组,在终止接触后,血清中胰岛素的水平显著降低,为26微单位/ml,而对照组为43.3微单位/ml。作者按照Navaratt的方法和评价标准(即在服用
The role of carbon disulfide (CS_2) in causing diabetes has not been systematically studied so far. According to reports by Austoni et al., There was a high incidence of diabetes in workers exposed to CS_2. However, Goto et al found no significant differences in glucose tolerance after exposure to CS_2. The authors of the very rigorous evaluation of many groups of workers exposed to CS_2, observed no significant increase in fasting blood glucose levels, and elevated blood glucose level has nothing to do with the length of contact. The experimental results of Abramova (1967) show that while in contact with CS_2, high-carbohydrate diets can cause diabetes. The authors observed no significant differences in glucose tolerance curves between exposed animals and control animals in chronic rat studies (exposure to CS2 concentrations of 1.2 and 2.4 mg / l). At 3.6 mg / l, concentrations, serum levels of insulin were significantly reduced at 26 microg / ml compared to 43.3 micrograms / ml in the control group after termination of the exposure. Authors follow Navaratt’s method and evaluation criteria (ie taking