结直肠纯鳞状细胞癌是一罕见临床疾病,对其自然病史和发病机制尚不清楚。文献所报道的病例数有限,有的随访也不完全。本文旨在研究结直肠鳞状细胞癌的最突出特点,以阐明其自然病史,便于改进诊断和治疗。本文共报道51例结直肠鳞状细胞癌,平均年龄54.2岁(32～90岁)。最常见的症状是腹痛,占22例。一般呈纯痛,但偶有中等程度。20例有直肠出血,出血程度不一,多属轻度。入院时3例有贫血(血红蛋白10 g 以下),5 Pure squamous cell carcinoma of the colorectum is a rare clinical disease, and its natural history and pathogenesis remain unclear. The number of cases reported in the literature is limited, and some follow-ups are not complete. This article aims to study the most prominent features of colorectal squamous cell carcinoma to elucidate its natural history and facilitate the improvement of diagnosis and treatment. A total of 51 colorectal squamous cell carcinomas were reported in this article, with an average age of 54.2 years (32 to 90 years). The most common symptom is abdominal pain, accounting for 22 cases. It is generally purely painful but occasionally moderate. Twenty patients had rectal bleeding, with varying degrees of bleeding, mostly mild. At the time of admission, there were 3 cases of anemia (less than 10 g of hemoglobin)5