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目的探究高血压合并阻塞性睡眠呼吸暂停综合征(OSAS)患者治疗前后的血压昼夜变化。方法 16例高血压患者,按照睡眠仪的检测结果分为单纯性高血压患者组(单纯患者组,8例)及合并OSAS患者组(合并患者组,8例),回顾性分析其临床就诊资料,对两组患者在治疗前后的血压昼夜变化进行统计分析。结果治疗前,单纯患者组有3例(37.5%)临床呈现非构型;合并患者组有7例(87.5%)I病床呈现非构型,两组患者的血压昼夜变化呈现非构型的比率对比,差异具有统计学意义(P<0.05)。经治疗后,单纯患者组有1例(12.5%)临床呈现非构型;合并患者组有3例(37.5%)临床呈现非构型,两组患者同治疗前相比,其血压的昼夜变化临床上非构型的比率均降低,合并患者组的降低更加显著,差异具有统计学意义(P<0.05)。结论临床上,高血压患者血压的昼夜变化如果呈现出非构型,则应考虑其为合并具有OSAS,经临床积极治疗,能够显著降低血压的昼夜变化非构型的比率。
Objective To investigate the changes of diurnal blood pressure before and after treatment in patients with hypertension and obstructive sleep apnea syndrome (OSAS). Methods Twenty-six patients with hypertension were divided into three groups according to the results of sleep test: simple hypertension group (n = 8) and OSAS group (n = 8). The clinical data , The two groups of patients before and after treatment of blood pressure changes in the diurnal statistical analysis. Results Before treatment, three patients (37.5%) in the pure patient group presented non-conformation, seven patients (87.5%) in the combined patient group presented non-conformation, and the diurnal variation of blood pressure in both patients presented a non-conformational ratio The difference was statistically significant (P <0.05). After treatment, one patient (12.5%) in the simple patient group presented non-conformation; three patients (37.5%) in the combined patient group presented non-conformation. The diurnal changes of blood pressure Clinically non-conformational ratio were reduced, the combined group of patients decreased more significantly, the difference was statistically significant (P <0.05). Conclusions Clinically, if the diurnal variation of blood pressure in hypertensive patients assumes non-conformation, it should be considered as the ratio of diurnal and non-conformational changes that can significantly lower the blood pressure when combined with OSAS.