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目的研究肿瘤坏死因子（ＴＮＦ）＋顺铂及单用顺铂治疗恶性胸腔积液的疗效及毒副反应。方法选取同期住院的经病理和（或）细胞学证实为恶性胸腔积液患者，分别给予ＴＮＦ＋顺铂及顺铂治疗。观察两组疗效及毒副反应。统计学处理方法：χ２检验。结果ＴＮＦ＋顺铂组有效率为８７％，单用顺铂组为６５％，Ｐ＜０．０１。两组毒副反应发生率分别为３８％和４２％，Ｐ＞０．０５。结论ＴＮＦ＋顺铂治疗恶性胸腔积液的疗效优于单用顺铂。而毒副反应无差别
Objective To investigate the efficacy and toxicities of TNF plus cisplatin and cisplatin alone in the treatment of malignant pleural effusions. Methods Patients with malignant pleural effusion confirmed by pathology and/or cytology in the same period of hospitalization were treated with TNF+cisplatin and cisplatin, respectively. Observe the efficacy and toxicity of the two groups. Statistical methods: χ2 test. Results The effective rate was 87% in the TNF+cisplatin group and 65% in the cisplatin alone group, P<0.01. The incidence of toxic and side effects in the two groups was 38% and 42%, respectively, P>0.05. Conclusions TNF+cisplatin is superior to cisplatin alone in the treatment of malignant pleural effusions. No difference in toxic side effects