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【目的】探讨TGF-α和TGF-β1的表达与肺腺癌患者预后的相关性。【方法】采用免疫组织化学染色方法(SABC法)检测63例肺腺癌中组织TGF-α和TGF-β1的表达,并用15例肺小细胞癌及20例癌旁正常肺组织作为对照。【结果】63例肺腺癌中,TGF-α阳性53例(84.1%),TGF-β1阳性40例(63.5%),与对照组有显著差异(P<0.01)。TGF-α阳性组术后生存期、五年生存率均低于阴性组(P<0.05)。TGF-β1阳性组术后生存期、五年生存率均低于阴性组(P<0.01)。存在淋巴结转移及临床Ⅱ、Ⅲ期患者TGF-β1阳性率高(P<0.01)。【结论】TGF-α和TGF-β1在肺腺癌中过表达,且过表达的肺腺癌患者预后较差,特别是TGF-β1,可作为肺腺癌有价值的预后标志。
【Objective】 To investigate the relationship between the expression of TGF-α and TGF-β1 and the prognosis of patients with lung adenocarcinoma. 【Methods】 The expression of TGF-α and TGF-β1 in 63 cases of lung adenocarcinoma was detected by immunohistochemical staining method (SABC method). Fifteen cases of small cell lung cancer and 20 cases of normal lung tissue adjacent to cancer were used as controls. 【Results】 Among the 63 cases of lung adenocarcinoma, 53 (84.1%) were positive for TGF-α and 40 (63.5%) were positive for TGF-β1, which was significantly different from the control group (P <0.01). The postoperative survival and the five-year survival rates of TGF-αpositive group were lower than those of negative group (P <0.05). The postoperative survival and the five-year survival rates of TGF-β1-positive group were lower than those of the negative group (P <0.01). The presence of lymph node metastasis and clinical stage Ⅱ, Ⅲ TGF-β1 positive rate (P <0.01). 【Conclusion】 TGF-α and TGF-β1 are overexpressed in lung adenocarcinoma, and over-expressed lung adenocarcinoma patients have poor prognosis, especially TGF-β1, which may be a valuable prognostic marker for lung adenocarcinoma.