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目的:探讨放疗同步化疗局部晚期宫颈癌患者的治疗效果。方法:对2008年1月至2009年月3月入我院肿瘤中心治疗的86例局部晚期宫颈癌患者按1∶1比例分为两组,每组各43例,对照组给予50~54 Gy盆腔照射,观察组患者在对照组基础上给予吉西他滨+顺铂(GP)进行化疗,化疗周期为21d,共化疗4~6个疗程,观察两组患者的治疗效果及毒副反应。结果:观察组患者完全缓解率明显高于对照组(χ2=4.305,P<0.01),差异具有统计学意义;观察组2、3年内复发率明显低于对照组(P<0.05)。结论:放疗同步化疗治疗晚期宫颈癌近期疗效确切,可明显改善患者的预后,提高患者生活质量。
Objective: To investigate the therapeutic effect of concurrent chemotherapy for locally advanced cervical cancer. Methods: A total of 86 patients with locally advanced cervical cancer who were admitted to our hospital from January 2008 to March 2009 were divided into two groups according to a ratio of 1: 1, with 43 cases in each group. The control group was given 50-54 Gy The patients in the observation group were given gemcitabine and cisplatin (GP) for chemotherapy on the basis of the control group. The chemotherapy cycle was 21 days and the courses of chemotherapy were 4 to 6 courses. The curative effect and toxicity of the two groups were observed. Results: The complete remission rate of the observation group was significantly higher than that of the control group (χ2 = 4.305, P <0.01). The difference was statistically significant. The recurrence rate of the observation group in 2 and 3 years was significantly lower than that in the control group (P <0.05). Conclusion: Radiotherapy concurrent chemotherapy for the treatment of advanced cervical cancer the exact effect of the recent, can significantly improve the prognosis of patients and improve the quality of life of patients.