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培哚普利(Perindopril,简称PER)是一种新的长效ACE抑制剂,具有强力动脉血管扩张作用。本文评价PER对充血性心衰(CHF)病人的体循环和局部血流动力学以及心功能的影响。 10例CHF病人参加了本研究。病人入院后均稳定至少6天。此期间,限钠(每日2g)和给予固定剂量的利尿剂,但试验前需停用利尿剂至少24小时。血管扩张剂或地高辛一律停用。所有病人单剂口服PER4mg前及以后,定时测定有关体循环和局部血流动力学参数。
Perindopril (PER) is a new long-acting ACE inhibitor with potent arterial vasodilation. This article evaluates the effects of PER on systemic and regional hemodynamics and cardiac function in patients with congestive heart failure (CHF). Ten patients with CHF participated in this study. Patients were stable for at least 6 days after admission. During this period, limiting sodium (2g daily) and given a fixed dose of diuretics, but need to stop diuretics before the test at least 24 hours. Vasodilators or digoxin will be disabled. All patients before and after a single oral dose of PER4mg, regular determination of systemic and local hemodynamic parameters.