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采用溶液法和固相法,合成了HBsAg Pre-S蛋白区域七个六肽片段。将其与载体蛋白结合。用多克隆抗HBsAg和单克隆抗“α”测定了肽—蛋白结合物的抗原特异性,结果表明P_1和P_5有较高的抗原特异性。
Seven hexapeptide fragments of HBsAg Pre-S protein were synthesized by solution method and solid-phase method. It binds to the carrier protein. The antigen specificity of the peptide-protein conjugates was determined by polyclonal anti-HBsAg and monoclonal anti-α, and the results showed that P_1 and P_5 have higher antigen specificity.