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使用牙髓失活法保存患牙,已有100多年历史,1936年Spooner氏首先使用亚砷酸,作为牙髓失活剂,1847年Wilzel氏将砷剂用于炎症牙髓,均获得满意效果,其后被广泛推广使用。但由于砷剂毒性所引起之严重并发症,且讫今尚未获得满意而准确的剂型,尚存在较大缺点,之后相继提出三聚(或多聚甲醛),中药失活剂等,三聚或多聚甲醛作用较缓和,效果好,因其对组织的破坏作用较小,一般不引起根尖周组织病变,更便于安全使用,但其失活作用过于缓慢,常需2至4周才能使牙髓失活,为
Dental pulp has been preserved for more than 100 years using dental pulp inactivation. In 1936, Spooner's first use of arsenious acid as a dental pulp inactivation agent, 1843 Wilzel's use of arsenic in inflammatory pulp, were satisfactory results , Then widely used. However, due to serious toxicity caused by arsenic toxicity complications, and this has not yet been satisfied with the exact dosage form, there are still major shortcomings, after they have been proposed trimerization (or paraformaldehyde), traditional Chinese medicine deactivator, trimerization or Paraformaldehyde is more potent and has good effect because it has less destructive effect on the tissue and generally does not cause periapical tissue lesions and is more convenient and safe to use. However, its inactivation is too slow and usually takes 2 to 4 weeks Dental pulp inactivation