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为揭示生长抑素在癫痫发生发展中的作用及其与癫痫患儿行为之间的关系，采用放射免疫法测定海人酸（ＫＡ）诱发癫痫动物模型脑组织与血浆生长抑素放射免疫活性（ＳＬＩ）。对２２例癫痫患儿进行血浆ＳＬＩ的检测和事件相关诱发电位的测查，并用Ａｃｈｅｎｂａｃｈ儿童行为量表进行评价。结果显示，动物额叶皮层内ＳＬＩ在注射ＫＡ后７天显著增高，可能与ＫＡ诱发动物癫痫敏感性增高有关。癫痫患儿血浆ＳＬＩ显著高于正常对照组，其行为异常发生率为４０．９％，Ｎ１００、Ｐ３００潜伏期均明显延长，血浆ＳＬＩ与攻击行为、多动行为呈显著负相关。提示癫痫发作后血浆ＳＬＩ的变化既反映了发作后生长抑素能神经元功能的改变，又可能是癫痫患儿行为异常或认知障碍的生物化学基础之一
To reveal the role of somatostatin in the development of epilepsy and its relationship with the behavior of children with epilepsy, radioimmunoassay was used to determine the radioimmunoassay of somatostatin in brain tissue and plasma of animal model of epilepsy induced by KA SLI). Twenty-two children with epilepsy were tested for plasma SLI and event-related evoked potentials, and were evaluated using the Achenbach Child Behavior Inventory. The results showed that the SLI in the frontal cortex of animals significantly increased at 7 days after injection of KA, which may be related to the increased sensitivity of KA-induced epilepsy in animals. The plasma SLI of children with epilepsy was significantly higher than that of the normal control group, the incidence of abnormal behavior was 40.9%, N100, P300 latency were significantly prolonged, plasma SLI and aggressive behavior, hyperactivity behavior was significantly negatively correlated. It is suggested that the change of plasma SLI after seizure not only reflects the change of somatostatin neurons function after the onset of seizures but also may be one of the biochemical foundations of behavioral disorders or cognitive impairment in children with epilepsy