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探讨了白三烯Ｂ４（ＬＴＢ４）、白三烯Ｃ４（ＬＴＣ４）及白三烯Ｄ４（ＬＴＤ４）对小鼠腹腔巨噬细胞分泌白细胞介素６（ｉｎｔｅｒｌｅｕｋｉｎ６，ＩＬ６）的影响。用ＩＬ６依赖细胞株Ｂ９的ＭＴＴ方法测定样品中ＩＬ６的含量。结果显示，ＬＴＢ４能剂量依赖性地增加巨噬细胞培养上清液中ＩＬ６的含量。ＬＴＣ４及ＬＴＤ４促进巨噬细胞培养上清液中ＩＬ６含量的最适浓度分别为：６９×１０－８和８０５×１０－８ｍｏｌ·Ｌ－１。结果提示：ＬＴＢ４与ＬＴＣ４及ＬＴＤ４在某些生物学功能方面有一致性。与ＬＴＣ４及ＬＴＤ４相比，ＬＴＢ４促进巨噬细胞培养上清液中ＩＬ６的含量的最适浓度则要大１～２个数量级，提示在炎症反应中，肽白三烯与ＩＬ６的相关性较强。
To investigate the effects of leukotriene B4 (LTB4), leukotriene C4 (LTC4) and leukotriene D4 (LTD4) on the secretion of interleukin 6 (IL6) in mouse peritoneal macrophages. With IL 6 dependent cell line B9 MTT method to determine the content of IL 6 in the sample. The results showed that, LTB4 dose-dependent increase in macrophage culture supernatant IL 6 content. LTC4 and LTD4 to promote macrophage cell culture supernatant IL 6 levels of the optimal concentrations were: 6 9 × 10-8 and 8 05 × 10-8mol·L-1. The results suggest that LTB4 and LTC4 and LTD4 are consistent in some biological functions. Compared with LTC4 and LTD4, LTB4 macrophage cell culture supernatant to promote the content of IL 6 the optimal concentration will be 1 to 2 orders of magnitude larger, suggesting that in the inflammatory response, peptide leukotriene and IL 6 Relatively strong.