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目的探讨快速检测D二-聚体(DD)在肺栓塞诊断中的临床意义。方法使用全自动免疫分析系统VIDAS DD测定法对可疑静脉血栓患者血浆中纤维蛋白降解产物D二-聚体进行检测,并对这些可疑肺栓塞患者进行1年随访,了解是否有肺栓塞症状。结果共有104例患者参加检测,32例患者的D二-聚体检测值<494ng/ml,72例患者血浆中D二-聚体检测值>494ng/ml,其中16例患者经肺通气、灌注扫描V/Q证实为肺栓塞,VIDAS DD法的敏感性为100%,阴性预期值为100%。结论VIDAS DD法可作为诊断栓塞的首选筛选方法。
Objective To investigate the clinical significance of rapid detection of D-dimer (DD) in the diagnosis of pulmonary embolism. Methods The plasma fibrinogen D-dimer in patients with suspected venous thromboembolism was detected by automatic immunoassay system VIDAS DD. Patients with suspected pulmonary embolism were followed up for one year to find out whether there was pulmonary embolism. RESULTS: A total of 104 patients were enrolled in this study. 32 patients had a D-dimer of 494 ng / ml and 72 patients had a D-dimer of 494 ng / ml. Sixteen of these patients received pulmonary ventilation and perfusion V / AS was confirmed as pulmonary embolism by VIDAS DD with a sensitivity of 100% and a negative predictive value of 100%. Conclusion VIDAS DD method can be used as the first screening method for diagnosis of embolism.