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本文作者通过临床资料综合分析,观察到高胆红素血症(特别是与其他肝功能检查不相称的直接胆红素升高)与儿童和成人的菌血症及其他严重感染有关。作者从美国衣阿华大学医院和威斯康星医学院附属医院肝病和传染病科就诊的病人中挑选有明确感染和总胆红素值>2mg/dl(正常<1.0mg/dl)者,进一步作肝功能检查。凡直接胆红素≥40％总胆红素者和在天门冬氨酸转氨酶(AST)、碱性磷酸酶(ALP)和丙氨酸转氨酶(ALT)升高的同时,总胆红素升高至少超过正常2倍者适合入选进行研究。符合标准的有19例成人患者(男12例,女7例)。对这些病人进行以下
Through comprehensive analysis of clinical data, the authors observed that hyperbilirubinemia (especially elevated direct bilirubin that is not commensurate with other liver function tests) is associated with bacteremia and other serious infections in children and adults. The authors selected patients with a definite infection and total bilirubin> 2 mg / dl (normal <1.0 mg / dl) from patients with hepatology and infectious diseases at the University of Iowa Hospital and the University of Wisconsin Medical Center to further develop liver Function check. Where direct bilirubin ≥ 40% of total bilirubin and aspartate aminotransferase (AST), alkaline phosphatase (ALP) and alanine aminotransferase (ALT) increased at the same time, total bilirubin At least 2 times more than normal, suitable for inclusion in the study. In line with the standard 19 adult patients (12 males and 7 females). The following for these patients