病毒性肝炎急性和亚急性肝萎缩引起重症肝功能衰竭的治疗极困难。交换输血一个治疗周期耗血达25升,交叉血循环包括利用供体和受体的脐静脉,在发展至昏迷状态时都很少见效;短暂联结异种动物的肝脏,亦仅有个别恢复的报告。即使用这些治疗,目前的病死率仍高达80％。肝功能衰竭时各种治疗效果不满意的一个可能原因是,药物进入病灶须经过一些生理屏障和滤器,如肺、肾、肠等,使浓度降低或其结构改变。局部治疗使药物直接进入病灶,可能提高疗效。因而作者对30例不同病因的黄疸病人应用脐静脉输注法,观察其疗效,并讨论此法治疗重症病毒性肝炎的可能性和合理性。举一病人为例,年龄47岁,发热当天入院,4日内病情迅速加重,出现黄疸,肝脏缩小,肝功能试验阳性,诊断为重症急性病毒性肝炎。病人旋即昏迷,对疼痛、对光有反应,呼吸有肝臭,尿量减少。经脐静脉输注液体、血液、血浆、皮质激素等。病程第11日, Viral hepatitis Acute and sub-acute liver atrophy causes the treatment of severe liver failure is extremely difficult. Exchange of blood transfusions consumes up to 25 liters of blood per treated cycle. Cross-circulation, including umbilical venous using donors and recipients, seldom works when developed to a coma; short-term ligation of xenogeneic livers has only reported individual recovery. Even with these treatments, the current case fatality rate is still as high as 80%. One of the possible reasons for dissatisfaction with various treatment effects in liver failure is that the drug enters the lesion through a number of physiological barriers and filters such as the lungs, kidneys, intestines, etc., reducing the concentration or changing its structure. Topical treatment to direct the drug into the lesion may improve the efficacy. Therefore, the author of 30 cases of jaundice patients with different causes of umbilical vein infusion to observe its efficacy, and discuss the possibility of this treatment of severe viral hepatitis and rationality. Take a patient as an example, age 47 years old, admitted to the hospital on the day of fever, the rapid deterioration of the disease within 4 days, jaundice, liver shrinkage, liver function test positive diagnosis of severe acute viral hepatitis. Immediately the patient coma, pain, light response, respiratory stools, decreased urine output. The umbilical vein infusion of liquid, blood, plasma, corticosteroids. On the 11th day,