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本文报道从中药丹参Salvia miltiorrhiza及甘西鼠尾S.przewalskii中分离得到的二萜醌及有关化合物42种对结核杆菌的抑菌作用,并研究了它们的构效关系。试验证实,醌式基团是抑菌的的必须基团,邻醌的抑菌强度高于对醌。A环的羟基化或环内脱氢均导致抑菌活性下降。丹参酮呋喃环的α-H的不同取代可明显影响抑菌活性。还讨论了醌类的抑菌强度与氧化还原电位值间可能存在某种联系。
This paper reports the antibacterial activity of 42 diterpenoids and related compounds isolated from Salvia miltiorrhiza and S. przewalskii, and their structure-activity relationships. The test confirmed that the quinone-type group is an essential antibacterial group, and the antibacterial strength of o-quinone is higher than that of antimony. Hydrolysis of the A ring or dehydrogenation in the ring leads to a decrease in the bacteriostatic activity. The different substitution of α-H of tanshinone furan ring can significantly affect the antibacterial activity. It is also discussed that there may be some link between the antibacterial intensity of the terpenes and the value of the redox potential.